As we age, our bodies accumulate senescent cells, often called "zombie cells." These cells stop dividing but don't die; instead, they release inflammatory molecules that can damage surrounding healthy cells and contribute to aging and age-related diseases. Senolytics are a class of compounds designed to selectively eliminate these senescent cells. This article, reviewed by our Medical Advisory Board, explores the science behind senolytics and the current state of research into their potential to extend healthspan.
Medically Reviewed: All clinical information on this page has been reviewed for accuracy by Dr. John Smith, PhD.
What are Senescent Cells?
Senescent cells are cells that have permanently stopped dividing but remain metabolically active. They accumulate in tissues with age and in response to various stressors, contributing to chronic inflammation and tissue dysfunction. Their presence is linked to conditions like arthritis, cardiovascular disease, and neurodegenerative disorders.
How Do Senolytics Work?
Senolytics work by targeting specific pathways that senescent cells rely on for survival. By disrupting these pathways, senolytics induce apoptosis (programmed cell death) in senescent cells, allowing the body to clear them. Common senolytic compounds include quercetin, fisetin, and dasatinib.
Current Research and Future Potential
Early research, primarily in animal models, has shown promising results, with senolytics demonstrating the ability to alleviate age-related symptoms, improve physical function, and extend lifespan. Human trials are ongoing, and while the results are not yet conclusive, senolytics represent a fascinating and rapidly developing area of longevity research.